for what it is worth this is how you “lsusb” in macOS:

$ ioreg -p IOUSB
+-o Root  <class IORegistryEntry, id 0x100000100, retain 36>
  +-o AppleT8112USBXHCI@01000000  <class AppleT8112USBXHCI, id 0x100000371, reg$
  | +-o Magic Keyboard@01100000  <class IOUSBHostDevice, id 0x100000d5a, regist$
  +-o AppleT8112USBXHCI@03000000  <class AppleT8112USBXHCI, id 0x1000003bb, reg$
  +-o AppleT8112USBXHCI@00000000  <class AppleT8112USBXHCI, id 0x1000003ca, reg$
  | +-o 4-Port USB 2.0 Hub@00100000  <class IOUSBHostDevice, id 0x100000a0e, re$
  | | +-o USB2.0 Hub             @00140000  <class IOUSBHostDevice, id 0x100000$
  | | +-o Rocksmith USB Guitar Adapter@00110000  <class IOUSBHostDevice, id 0x1$
  | +-o 4-Port USB 3.0 Hub@00200000  <class IOUSBHostDevice, id 0x100000a10, re$
  |   +-o RTL9210B-CG@00220000  <class IOUSBHostDevice, id 0x100000a43, registe$
  |   +-o USB3.0 Hub             @00240000  <class IOUSBHostDevice, id 0x100000$
  |     +-o USB3.0 Card Reader@00243000  <class IOUSBHostDevice, id 0x100000a71$
  +-o AppleT8112USBXHCI@02000000  <class AppleT8112USBXHCI, id 0x10000036e, reg$
  | +-o Scarlett 4i4 USB@02100000  <class IOUSBHostDevice, id 0x100000a56, regi$
  +-o AppleEmbeddedUSBXHCIASMedia3142@08000000  <class AppleEmbeddedUSBXHCIASMe$
    +-o USB Receiver@08300000  <class IOUSBHostDevice, id 0x100000a2f, register$
    +-o YubiKey FIDO+CCID@08400000  <class IOUSBHostDevice, id 0x100000a37, reg$

ioreg is a wrapper utility for doing queries from https://developer.apple.com/documentation/iokit

just learned this and now i’ll probably remember it too after writing this ;-)

I'm trying to figure out how to get this to used in the Steam version of Rocksmith 2014 running with CrossOver:

IOUSBHostDevice, id 0x100000$
| | +-o Rocksmith USB Guitar Adapter@00110000 <class

There is macOS version of the game at Steam but unfortunately macOS Sequoia broke it, and it goes without saying that Ubisoft will not fix it ;-)

It runs otherwise with zero tweaks required and zero glitches appearing with CrossOver. I'll definitely buy it, if the cable starts working too. There's bunch of free alternatives but I'll just want to get the fucking game working and get on with my life. Definitely worth of paying the discounted price of 51 euros and 80 cents at least (up until 11th of July) ;-)

what a depressing situation really, and weekend is ruined as i cannot do things i like to do on free time but i'll get there!

https://www.codeweavers.com/compatibility/crossover/tips/rocksmith-2014-pc/how-to-run-rockmith-2014-with-crossover-linux

So... I think for Audio CrossOver is not a great idea. I came to this conclusion after trying out if it could re-enable Rocksmith in macOS.

It's much better idea to run it on an emulated VM for the sake of USB passthrough. Graphics is not high-end in that game and then it will work with audio with best possible quality of service.